\documentclass{standalone}

\usepackage[utf8]{inputenc}

\usepackage{pgfplots}
\pgfplotsset{compat=1.3}
\usepgfplotslibrary{units}
\usepgfplotslibrary{dateplot}
\usepackage{tikz}
\usepackage{pgfplotstable}
\usepackage{csquotes}
\usepackage{float}

\begin{document}

\pgfplotstableread{
size rate pps
1500	986.004	82167
1450	985.7216	84976
1400	984.7376	87923
1350	984.2904	91138
1300	983.4968	94567
1250	982.78	98278
1200	982.08	102300
1150	981.18	106650
1100	980.2496	111392
1050	979.2384	116576
1000	978.304	122288
950	977.36	128600
900	975.0024	135417
850	974.27	143275
800	972.5888	151967
750	970.572	161762
700	968.3856	172926
650	966.2328	185814
600	963.1056	200647
550	959.7588	218127
500	955.604	238901
450	951.588	264330
400	945.3248	295414
350	937.3336	334762
300	923.2584	384691
250	855.588	427794
200	662.5952	433335
150	527.3604	439467
100	354.96	443700
50	207.176	446500
}\sizeratepps

\begin{tikzpicture}
\pgfplotsset{
    y axis style/.style={
        yticklabel style=#1,
        y axis line style=#1,
        ylabel style=#1,
        ytick style=#1
   }
}
    \begin{axis}[
        width=15cm, height=10cm,
        title=Sender,
        xmin=1,
        xmax=1500,
        xlabel={Ethernet Frame-Größe [Byte]},
        xtick={100,300,500,700,900,1100,1300,1500},
        ymin=0,ymax=1000,
        axis y line*=left,
        ylabel={Datenrate [MBit/s]},
        y axis style=blue!75!black,
		tick label style={/pgf/number format/fixed,/pgf/number format/1000 sep = \thinspace},
        scaled ticks=false
    ]
    \addplot[smooth,blue] table[x={size}, y={rate}] {\sizeratepps};
    \end{axis}
    \begin{axis}[
        width=15cm, height=10cm,
        xmin=1,
        xmax=1500,
        axis x line=none,
        ymin=0,ymax=500000,
        ytick pos=right,
        axis y line* = right,
        ylabel={Pakete pro Sekunde},
        ylabel near ticks,
        ytick={100000,200000,300000,400000},
        y axis style=red!75!black,
		tick label style={/pgf/number format/fixed,/pgf/number format/1000 sep = \thinspace},
        scaled ticks=false
      ]
    \addplot[smooth,red] table[x={size}, y={pps}] {\sizeratepps};
    \end{axis}
\end{tikzpicture} 


\end{document}